|Season(s)||1, 2, 3|
|Portrayed by||Peter Sullivan|
|First appearance||The Poisoned Chalice|
|Latest appearance||The Prince|
|House||House of Sforza|
|Other relatives|| Giovanni Sforza (cousin: deceased)|
Catherina Sforza (cousin)
Ludovico Sforza (cousin)
Gian Galaezzo (cousin)
Gabriella Visconti (cousin)
- "I have long forsaken old ties with my family. I'm a nameless orphan in the service of God, my pope, and the Borgia family."
- ―Ascanio Sforza
Ascanio Sforza is a powerful cardinal and vice chancellor in the church.
One of the Borgias' most trusted confidantes also happens to be a Sforza, Catherina's cousin. He's a powerful cardinal who becomes chancellor in a deal with Rodrigo Borgia to elect Borgia as pope. Ascanio arranged the marriage between Lucrezia Borgia and his cousin, Giovanni Sforza. With the two families locked in a dangerous power struggle, the good cardinal just might be the key to its resolution, depending on which side he chooses to take.
|Season one appearances|
|The Poisoned Chalice||The Assassin||The Moor|
|Lucrezia's Wedding||The Borgias in Love||The French King|
|Death, on a Pale Horse||The Art of War||Nessuno (Nobody)|
|Season two appearances|
|The Borgia Bull||Paolo||The Beautiful Deception||Stray Dogs||The Choice|
|Day of Ashes||The Siege at Forli||Truth and Lies||World of Wonders||The Confession|
|Season three appearances|
|The Face of Death||The Purge||Siblings||The Banquet of Chestnuts||The Wolf and the Lamb|
|Relics||Lucrezia's Gambit||Tears of Blood||The Gunpowder Plot||The Prince|