|Portrayed by||Peter Stebbings|
|First appearance||The Face of Death|
|Latest appearance||The Purge|
De Luca is a cardinal. When he refused to take the blame for the plot to kill the Borgia family, he was tortured.
|Season three appearances|
|The Face of Death||The Purge||Siblings||The Banquet of Chestnuts||The Wolf and the Lamb|
|Relics||Lucrezia's Gambit||Tears of Blood||The Gunpowder Plot||The Prince|